Gene name:
INTS3(C1orf193;C1orf60);
Protein name:
Integrator complex subunit 3(Int3);
Alternative:
Sensor of single-strand DNA complex subunit A(SOSS-A;Sensor of ssDNA subunit A);SOSS complex subunit A;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, CPSF3L/INTS11 and INTS12. Component of the SOSS complex, composed of SOSS-B (SOSS-B1/OBFC2B or SOSS-B2/OBFC2A), SOSS-A/INTS3 and SOSS-C/C9orf80. SOSS complexes containing SOSS-B1/OBFC2B are more abundant than complexes containing SOSS-B2/OBFC2A. Interacts with SOSS-B1/OBFC2B, SOSS-B2/OBFC2A and SOSS-C/C9orf80; the interaction is direct. Interacts with NBN/NBS1.
Function:
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.
Subcellular Location:
Nucleus
Localizes to nuclear foci following DNA damage.
Protein Attributes:
50:
MELQKGKGAA | AAAAASGAAG | GGGGGAGAGA | PGGGRLLLST | SLDAKDELEE |
100:
RLERCMSIVT | SMTAGVSERE | ANDALNAYVC | KGLPQHEEIC | LGLFTLILTE |
150:
PAQAQKCYRD | LALVSRDGMN | IVLNKINQIL | MEKYLKLQDT | CRTQLVWLVR |
200:
ELVKSGVLGA | DGVCMTFMKQ | IAGGGDVTAK | NIWLAESVLD | ILTEQREWVL |
250:
KSSILIAMAV | YTYLRLIVDH | HGTAQLQALR | QKEVDFCISL | LRERFMECLM |
300:
IGRDLVRLLQ | NVARIPEFEL | LWKDIIHNPQ | ALSPQFTGIL | QLLQSRTSRK |
350:
FLACRLTPDM | ETKLLFMTSR | VRFGQQKRYQ | DWFQRQYLST | PDSQSLRCDL |
400:
IRYICGVVHP | SNEVLSSDIL | PRWAIIGWLL | TTCTSNVAAS | NAKLALFYDW |
450:
LFFSPDKDSI | MNIEPAILVM | HHSMKPHPAI | TATLLDFMCR | IIPNFYPPLE |
500:
GHVRQGVFSS | LNHIVEKRVL | AHLAPLFDNP | KLDKELRAML | REKFPEFCSS |
550:
PSPPVEVKIE | EPVSMEMDNH | MSDKDESCYD | NAEAAFSDDE | EDLNSKGKKR |
600:
EFRFHPIKET | VVEEPVDITP | YLDQLDESLR | DKVLQLQKGS | DTEAQCEVMQ |
650:
EIVDQVLEED | FDSEQLSVLA | SCLQELFKAH | FRGEVLPEEI | TEESLEESVG |
700:
KPLYLIFRNL | CQMQEDNSSF | SLLLDLLSEL | YQKQPKIGYH | LLYYLRASKA |
750:
AAGKMNLYES | FAQATQLGDL | HTCLMMDMKA | CQEDDVRLLC | HLTPSIYTEF |
800:
PDETLRSGEL | LNMIVAVIDS | AQLQELVCHV | MMGNLVMFRK | DSVLNILIQS |
850:
LDWETFEQYC | AWQLFLAHNI | PLETIIPILQ | HLKYKEHPEA | LSCLLLQLRR |
900:
EKPSEEMVKM | VLSRPCHPDD | QFTTSILRHW | CMKHDELLAE | HIKSLLIKNN |
950:
SLPRKRQSLR | SSSSKLAQLT | LEQILEHLDN | LRLNLTNTKQ | NFFSQTPILQ |
1000:
ALQHVQASCD | EAHKMKFSDL | FSLAEEYEDS | STKPPKSRRK | AALSSPRSRK |
1043:
NATQPPNAEE | ESGSSSASEE | EDTKPKPTKR | KRKGSSAVGS | DSD
Vaild Sequence:
Related Databases
Uniprot: